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Biofabrications with much promising Bioprinter
The spending on health cares of the the US amounted to 25,095 hundred million US dollars in 2009, accounting for 17.6% of US GDP, 40% of national income and is expected to reach 43,532 hundred million dollars to 2018, acounted for 20.3% GDP. (United States Department of Health and Human Services, http://www.hhs.gov/)
Among these demands, the Biofabrication has consistant increasing contribution in the huge biomedical research and clinical applications. 
Biofabrication is persistently and rapidly developing with the improvement of biomaterials--bioinks and advanced bioprinter technologies, allowing us to build biofabrication systems including for,

1. Bone tissue repair and regeneration
2. Complexed scaffolds for soft tissues
3. Cell proliferation, migration, and tissue formation 
4. Drug testing, discovery and screening
5. Medical aid, wond healing
6. Diseased tissue and oganisim models, etc.

HyperLink

To achieve a realistic time frame for building organized clinically-relevant sizes biofabrication constructs, we Regenovo_ABDC) have extensive emphasis on the Robotic Dispensing Bioprinter, among others types of bioprinters(as that of  the stereolithography (light-curing), electrospinning, laser induced forward transfer, inkjet modules that we could include as addition modules), is the most promising bio-printer both for spatial resolution, print speed, material and cost considerations. 

Table 1. Typical characteristics of three key dispensing approaches in biofabrication

  Laser-induced forward transfer Inkjet printing Robotic dispensing
Resolution ++ + +/-
Fabrication speed - +/- ++
Hydrogel viscosity +/- - +
Gelation speed ++ ++ +/-

Reference: Advanced Materials, 25th Anniversary Article:
Engineering Hydrogels for Biofabrication--3 Hydrogel Based Biofabrication Systems
http://onlinelibrary.wiley.com/wol1/doi/10.1002/adma.201302042/full

Base on these key considerations and demands for our bioprinters , we have continous efforts to improve resolution, stability, flexibility and most affordable cost for researchers and clinical developers.  

Features of our Bioprinter

1. Viable cells/biomaterial 3D printing,  most cell survival ratio, much cell than 90%, for longest survival of 4 months, , with global technology leading levels for the living cells printing.   
Based on Robotic dispensing, printable materials are "Unrestricted", as solution, slurry, gel or melt, etc., with high freedom of choices.  

2. The solid state cooling and heating temperature control system
Using an independent solid state cooling elements, and by the liquid heat transfer medium and micro-flow channel network, to realize the  thermal conductivity and temperature control for the print stage and nozzle. The system is highly integrated with precise temperature control, easy extention and operation.  

3. Specially designed unique multi-nozzles technology
Multi-nozzles can be manually or automatically loaded/exchanged for interleaved 3D, multi-material heterogenously located, and multi-layer, multi process steps constructions. 
High-temperature nozzle temperature range 50-260
, low temperature nozzle range for -5-65, can be used to print biological materials that could be melt in between -5 to 260 or in semi-fluid state.
The High-temperature nozzle is manufactured by integrally molded 3D printing technology(SLS), with the optimal design of the heat exchange efficiency, and supports the molten state biological material printing from 50 to 260 .
The Low temperature nozzle can cover -5 (-20 option) to 65 precise temperature control, specially oriented low temperature print way to ensure the vitally active state of soft tissue biomaterials.  
The pneumatic extrusion
nozzle type may have least or have no material leakage while the extrusion is paused or the  position is shifted.
The screw extruder nozzle type can produce high extrusion propulsion power, that is suitable for extrusion of high pressure tolerance and viscosity materials.

4. The precise temperature control:  Localized temperature control with accuracy of +/- 0.1
, ensuring a constant temperature and cell activity and can realize best spatial repeatability and process reproducibility of the bio-fabrication.

5. Precise controllable internal porosity and ways to print with multiple anglesensuring that the internal holes of the porous structure are 100% connected, providing similarity as in vivo cell growth microenvironment.  

6. Clean Design
The overall structure and materials of the 3D printing system are sterile design to ensure a clean working environment and processes, and are suitable for 3D printing of biological materials and cells under sterile conditions.  
Integrated supported professional sterile equipment, ensuring chance of contamination is less than 10%.  
 

7. Print Stage space
Large molding range, 160 x 160 x 150mm. with custom range available.
 

8. Display, editing and controls of a three-dimensional models
Implement features such as view, rotate, scale, move and mirror of 3D model, 3D model slicing, and motion stage and 3D model printing controls, etc. 
Free design with CAD softwares, have external shape and internal structure according to the model implementation requirements.

9. Integrated development teams
Integrated developed by Regenovo Biotechnology Co.Ltd. and Hangzhou University of Electronic Science and Technology, with completely independent intellectual property rights, and can implement partial customization according to specific user requirements to realize adjustable and diverse needs.  

10. Solid Living Cell Print foundation:  Professor Xu Mingen, our chief scientist and colleagues have dedicated in Cell-Printing for more than 8 years, and have prominent contributions in the bio-3D Print field. 

Generic Specifications
Air pressure: 0.6-0.8Mpa
Support plate: -5 ~ 65
/-20~65
Size & Weight: 64x50x70cm/50kg or 85x61x65cm/150kg
Data format: direct support for STL, GCODE, and customized proprietary format.
Operating System: Windows System
Power supply: 100-240V AC, 20A, 50/60Hz
Nozzle cleaning: with self-cleaning function
Customizable options
a.Lab & manufacturing process optimization.
b.
Additional modules, as : Stereolithography (Light-Curing), Electrospinning, L
aser induced forward transfer modules,etc.

Cooperative partners

Based on progressive and open main frame, we have vigorous and intensive cooperations with our partners and power users in many advanced institutions, for instrument optimization, integrated process optimization, bio-material conditioning and tuning, to advanced bio-print and bio-fabrication projects and goals.
Part of our consitantly increasing partners:
Affiliated Hospital of People's Liberation Army General Hospital (304)

Brain Hospital of Tianjin, China Armed Police (Armed Forces Institute of traumatic brain injury and neurological disease)
Affiliated Drum Tower Hospital of Nanjing University
West China Hospital, Sichuan University, Research Center for Regenerative Medicine
117 Hospital of People's Liberation Army
Guangzhou Medical College
Stomatology Hospital of Zhejiang University (Biomedical Engineering and Instrument Science)
Hangzhou University of Electronic Science and Technology (Institute of Bio-medical engineering and instrumentation)
South China University of Technology (country rebuild human tissue engineering technology research center)
Shanghai Jiaotong University (State Key Laboratory of Metal Matrix Composites) ), etc...

 

We (Regenovo_ABDC) are a global technology and markiting partners, and cooperate seamlessly with research institutions, industry, universities, users for practical demands and successfully developed 3D-BioPrinting systems with independent intellectual properties and provide our users with flexible advantages, as expansion, modification, and innovative R&D applications.
Welcome to correspond for discussing your current demand and future developments.
http://www.chromnet.net/

The Regenovo is a high-tech enterprises specialized to provide integrated 3D Bio-Printing technology solutions in the biomedical field, and committed to the development of Bio-Printers bio-materials and software in the biomedical fields, with core research and development technologies.

http://regenovo.com/

HyperLink  

(Click image for large images)
HyperLink  HyperLink  HyperLink  HyperLink

We (ABDC) have more than 20 years continuous efforts in the research and production of lab instrument, software and hardware, and have experiences on the 3D bio and food printing technology.
http://www.chromnet.net/

The Shining 3D Technology(Shining), is the largest 3D scanning and printing-related product development and distribution company, and also is one of the major technical partner of Regenovo. 
http://www.shining3d.cn/zh-cn/

Media/Video

CCTV_InterviewVideos.avi

3D BioPrinting--Human Organs Introduction Videos 0001.flv

(Download Free FLV Player : http://applian.com/flvplayer/)

3D BioPrinting--Human Organs Introduction Videos 0002.flv

3D BioPrinting--Human Organs Introduction Videos 0003.flv

3D BioPrinting--Human Organs Introduction Videos 0004.flv

CCTV4 report .zip (mpg) report .zip (mpg)

Regenovo biomaterials_SLA.avi

Regenovo Cell print.avi

Reuters-Chinese bio-printer to ease national organ short.flv

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96. Bioprinting Endothelial Cells With Alginate for 3D Tissue Constructs
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97. A phase diagram for microfabrication of geometrically controlled hydrogel scaffolds
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