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Enantiomer ( Chiral ) Separation Chromatography - Features & Application Examples

ULTRON ES-OVM-3
Stationary Phase : Ovomucoid
https://en.wikipedia.org/wiki/Ovomucoid

Features:
・Maximum operating pressure of 30 MPa.
・Can be used in LC/MS systems as well.
・Employs a 3 µm packing material for higher peak resolution and theoretical plate numbers.
・Enables significant reductions in analysis times while maintaining high theoretical plate numbers.
・Enables further improvements in performance with optimization of LC system tubing and flow cells.
・9 column length and inner diameter combinations available.

Applications
・Pharmaceuticals ・Pesticides ・Organic synthetic compounds
HyperLink

Applications

Samples, Wiki-Inf

Chromatograms

LC

Amlodipine

Amlodipine

 HyperLink

LC

Atomoxetine Hydrochloride

Atomoxetine Hydrochloride

 HyperLink

LC

Candesartan Cilexetil

Candesartan Cilexetil

 HyperLink

LC

Carvedilol

Carvedilol

 HyperLink

LC

Cetirizine Hydrochloride

Cetirizine Hydrochloride

 HyperLink

LC

Duloxetine Hydrochloride

Duloxetine Hydrochloride

 HyperLink

LC

Formoterol Fumarate

Formoterol Fumarate

 HyperLink

LC

Ibuprofen

Ibuprofen

 HyperLink

 

ULTRON ES-OVM, ULTRON ES-OVM-C
Stationary Phase : Ovomucoid
https://en.wikipedia.org/wiki/Ovomucoid

Features:
・Employ a highly denaturation resistant protein (ovomucoid) ligand.
・Display a wide range of chiral recognition.
・No sample pretreatment required for chiral separations.
・Can be used for reversed-phase analyses. ・Trace analyses possible (several nanograms).
・[ULTRON ES-OVM-C] Clopidogrel bisulfate evaluation conditions based on USP standards employed for shipping inspections.
・[ULTRON ES-OVM-C] Low viscosity 30% acetonitrile aqueous solution used as column storage solvent.

Applications
・Pharmaceuticals ・Pesticides ・Organic synthetic compounds
HyperLink

Applications

Samples, Wiki-Inf

Chromatograms

 

LC

(1S,2R)-1-Methyl cis-1,2,3,6-Tetrahydrophthalate

(1S,2R)-1-Methyl cis-1,2,3,6-Tetrahydrophthalate

HyperLink

LC

1,2-Diphenylethylamine

1,2-Diphenylethylamine

HyperLink

LC

Oxprenolol

Oxprenolol

HyperLink

LC

β-Blocking agent

Bunitrolol

 HyperLink

LC

closed

 HyperLink

LC

β-Blocking agent

Arotinolol

 HyperLink

LC

β-Blocking agent

Pindolol

 HyperLink

LC

β-Blocking agent

Propranolol

 HyperLink

LC

The effect of the column temperature (Propranolol)

Propranolol

 HyperLink

LC

Calcium rivalry medicine

Bay K 8644

 HyperLink

LC

Calcium rivalry medicine

Verapamil

 HyperLink

LC

Calcium rivalry medicine

Prenylamine

 HyperLink

LC

Bronchodilator agent

Clorprenaline

 HyperLink

LC

The local anesthetic

Bupivacaine

 HyperLink

LC

Muscle relaxant

Chlormezanone

 HyperLink

LC

Muscle relaxant

Tolperisone

 HyperLink

LC

Antihypertensive diuretic

Ethiazide

 HyperLink

LC

Analysis of the antidepressive drug

Trimipramine Maleate

 HyperLink

LC

Flurbiprofen

Flurbiprofen

 HyperLink

LC

Ibuprofen

Ibuprofen

 HyperLink

LC

Antiinflammatory agent

Ketoprofen

 HyperLink

LC

Antiinflammatory agent

Pranoprofen

 HyperLink

LC

Antiinflammatory agent

Zaltoprofen

 HyperLink

LC

closed

 HyperLink

LC

Anticholinergic agent

Mepenzolate bromide

 HyperLink

LC

Antipsychotic drug

Thioridazine

 HyperLink

LC

Antiepileptic

Mephobarbital

 HyperLink

LC

Antiepileptic

Acetylpheneturide

 HyperLink

LC

Antiparkinsonic agent

Biperiden

 HyperLink

LC

Antiparkinsonic agent

Profenamine

 HyperLink

LC

Antiparkinsonic agent

Trihexyphenidyl

 HyperLink

LC

Antihistaminic drug

Alimemazine

 HyperLink

LC

Antihistaminic drug

Chlorpheniramine

 HyperLink

LC

Antihistaminic drug

Dimethindene maleate

 HyperLink

LC

Antihistaminic drug

Homochlorcyclizine

 HyperLink

LC

Antihistaminic drug

Promethazine

 HyperLink

LC

Antianxiety agent

Hydroxyzine

 HyperLink

LC

Disopyramide phosphate

Disopyramide phosphate

 HyperLink

LC

Hypnotic

Glutethimide

 HyperLink

LC

Hypnotic

Hexobarbital

 HyperLink

LC

Peptic ulcer agent

Proglumide

 HyperLink

LC

closed

 HyperLink

LC

Thyroxine

Thyroxine

 HyperLink

LC

Antitussive drug

Benproperine

 HyperLink

LC

Meclizine

Meclizine

 HyperLink

LC

Application to pharmacokinetics analysis using the narrow bore column

Warfarin

 HyperLink

LC

Flavonoid

Flavanone

 HyperLink

LC

Benzoin

Benzoin

 HyperLink

LC

Muscle relaxant

Chlorphenesin

 HyperLink

LC

Muscle relaxant

Eperisone

 HyperLink

LC

Antitussive drug

Cloperastine

 HyperLink

LC

The effect of the column temperature (Maleic acid trimipramine)

Trimipramine Maleate

 HyperLink

LC

2-(4-Hydroxyphenoxy)propionic acid

2-(4-Hydroxyphenoxy)propionic acid

 HyperLink

LC

3,3-dimethyl-4-phenyl-2-azetidinone

3,3-dimethyl-4-phenyl-2-azetidinone

 HyperLink

LC

Aminoglutethimide

Aminoglutethimide

 HyperLink

LC

Amlodipine

Amlodipine

 HyperLink

LC

Benidipine Hydrochloride

Benidipine Hydrochloride

 HyperLink

LC

Bepotastine Besilate

Bepotastine Besilate

 HyperLink

LC

Bepridil hydrochloride

Bepridil hydrochloride

 HyperLink

LC

Bicalutamide

Bicalutamide

 HyperLink

LC

Bromacil

Bromacil

 HyperLink

LC

Brompheniramine maleate

Brompheniramine maleate

 HyperLink

LC

Candesartan Cilexetil

Candesartan Cilexetil

 HyperLink

LC

Cyclobenzaprine Hydrochloride

Cyclobenzaprine Hydrochloride

 HyperLink

LC

Duloxetine Hydrochloride

Duloxetine Hydrochloride

 HyperLink

LC

EDDP perchlorate

EDDP perchlorate

 HyperLink

LC

Ezetimibe

Ezetimibe

 HyperLink

LC

Omeprazole

Omeprazole

 HyperLink

LC

Ornidazole

Ornidazole

 HyperLink

LC

Amlodipine

Amlodipine

 HyperLink

LC

Atomoxetine Hydrochloride

Atomoxetine Hydrochloride

 HyperLink

LC

Atomoxetine Hydrochloride

Atomoxetine Hydrochloride

 HyperLink

LC

Azelnidipine

Azelnidipine

 HyperLink

LC

Bupropion Hydrochloride

Bupropion Hydrochloride

 HyperLink

LC

Candesartan Cilexetil

Candesartan Cilexetil

 HyperLink

LC

Carvedilol

Carvedilol

 HyperLink

LC

Carvedilol

Carvedilol

 HyperLink

LC

Cetirizine Hydrochloride

Cetirizine Hydrochloride

 HyperLink

LC

Cetirizine Hydrochloride

Cetirizine Hydrochloride

 HyperLink

LC

Doxylamine succinate

Doxylamine succinate

 HyperLink

LC

Duloxetine Hydrochloride

Duloxetine Hydrochloride

 HyperLink

LC

Escitalopram Oxalate

Escitalopram Oxalate

 HyperLink

LC

Formoterol Fumarate

Formoterol Fumarate

 HyperLink

LC

Formoterol Fumarate

Formoterol Fumarate

 HyperLink

LC

Ibuprofen

Ibuprofen

 HyperLink

 



ULTRON ES-PEPSIN
Stationary Phase : Pepsin
https://en.wikipedia.org/wiki/Pepsin

Features:
・Employs the polypeptide splitting enzyme pepsin (obtained from pig stomach linings), which is chemically bonded to the base material in an extremely stable manner.
・Displays superior performance with respect to chiral separations of aminoalcohol pharmaceuticals such as beta blockers.
・No sample pretreatment required for chiral separations. ・Can be used for reversed-phase analyses.
・Trace analyses possible (several nanograms).

Applications

・Pharmaceuticals ・Pesticides ・Organic synthetic compounds
HyperLink

LC

Applications

Samples, Wiki-Inf

Chromatograms

LC

Atenolol

Atenolol

LC

β-Blocking agent

Alprenolol

LC

β-Blocking agent

Bufetolol

LC

Bronchodilator agent

Terbutaline

LC

Bronchodilator agent

Salbutamol


ULTRON ES-BSA
Stationary Phase : Bovine serum albumin
https://en.wikipedia.org/wiki/Bovine_serum_albumin

Features:
・Employs bovine serum albumin, which is chemically bonded to the base material in an extremely stable manner.
・Provides superior chiral separations of acidic compounds such as arylpropionic acid pharmaceuticals.
・No sample pretreatment required for chiral separations.
・Can be used for reversed-phase analyses.
・Trace analyses possible (several nanograms).

Applications
・Pharmaceuticals ・Pesticides ・Organic synthetic compounds
HyperLink

 

Applications

Samples, Wiki-Inf

Chromatograms

 

LC

Amino acid

Tryptophan

 

 

LC

Synthesis starting material of the arylpropionic acid system drug

α-Phenylpropionic acid

 

 

LC

Oral anticoagulant

Warfarin

 

 

LC

Antiinflammatory agent

Ibuprofen

 

 

LC

Antiinflammatory agent

Fenoprofen Calcium

 

 

LC

Antiinflammatory agent

Ketoprofen

 

 

LC

Antiinflammatory agent

Pranoprofen

 

 

LC

Hypnotic

Oxazepam

 

 

LC

Hypnotic

Lorazepam

 

 

LC

Pyridon carboxylic acid antibacterial agent

Ofloxacin

 

 

LC

Benzoin

Benzoin

 

 

ULTRON ES-CD, ULTRON ES-PhCD
SULTRON ES-CD and ULTRON ES-PhCD columns are chiral separation columns employing chemically bonded beta-cyclodextrin (CD) and a beta-cyclodextrin derivative (PhCD) as stationary phases.

Stationary Phase : Cyclodextrin
https://en.wikipedia.org/wiki/Cyclodextrin

HyperLink

Features:
・Capable of chiral separations of hydrophobic cyclic compounds.
・Both reverse and no
rmal phase eluents can be used.
・Chiral separations of a wide range of compounds are possible using these two types of columns.
・Display superior stability and durability.

Applications
・Pharmaceuticals ・Pesticides ・Organic synthetic compounds

Applications

Samples, Wiki-Inf

Chromatograms

LC

Ethiazide

Ethiazide

 

LC

Bronchodilator agent

Terbutaline

 

LC

closed

 

LC

Muscle relaxant

Eperisone

 

LC

Chlorprenaline

Chlorprenaline

 

LC

Chlormezanone

Chlormezanone

 

LC

Antihistaminic drug

Alimemazine

 

LC

Thioridazine

Thioridazine

 

LC

The central neuron stimulant

Methylphenidate

 

LC

Trimipramine

Trimipramine

LC

Flavanone

Flavanone

 

LC

Hexobarbital

Hexobarbital

 

LC

Benzoin

Benzoin

 

LC

Chlorpheniramine maleate

Chlorpheniramine Maleate

 

LC

Mephobarbital

Mephobarbital

 

LC

The relationship between dosage of the organic solvent and capacitor ratio (k'), and optics recognition ability (α)

PTH-Valine

 

LC

Bepotastine Besilate

Bepotastine Besilate

 

LC

2-(4-Hydroxyphenoxy)propionic acid

2-(4-Hydroxyphenoxy)propionic acid

 

LC

3,3-dimethyl-4-phenyl-2-azetidinone

3,3-dimethyl-4-phenyl-2-azetidinone

 

LC

Bicalutamide

Bicalutamide

 

LC

Cyclobenzaprine Hydrochloride

Cyclobenzaprine Hydrochloride

 

LC

Ezetimibe

Ezetimibe

 

LC

1,1'-Bi-2-Naphthol

1,1'-Bi-2-Naphthol

 

LC

α-Phenylethylamine

α-Phenylethylamine , (S)-(-)-α-Methylbenzylamine

 

LC

α-Phenylethylalchol

α-Phenylethylalchol

 

LC

β-Blocking agent

Propranolol

 

LC

Antiepileptic

Acetylpheneturide

 

LC

Atenolol

Atenolol

 

LC

Alprenolol

Alprenolol

 

LC

Arotinolol

Arotinolol

 

LC

The local anesthetic

Bupivacaine

 

LC

Muscle relaxant

Eperisone

 

LC

Muscle relaxant

Chlormezanone

 

LC

Muscle relaxant

Chlorphenesin

 

LC

Analysis in normal phase mobile phase

trans-Stilben Oxide

 

LC

Analysis in normal phase mobile phase

N-(3,5-Dinitrobenzoyl)-α-Methylbenzylamine

 

LC

Analysis in normal phase mobile phase

Flavanone

 

LC

Pindolol

Pindolol

 

LC

β-Blocking agent

Bunitrolol

 

LC

Propranolol

Propranolol

 

LC

The relationship between flow ratio and capacitor ratio (k') of column temperature, optics recognition ability (α)

α-Phenylethylalchol

 

LC

Duloxetine hydrochloride

Duloxetine hydrochloride

 

LC

Ezetimibe

Ezetimibe

 

LC

Ipratropium bromide

Ipratropium bromide

 



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