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Engineered Cells for Science and Pharma

          

Bio-Technology Raw Materials and Consumables from Taiwan

Knowledge Bases
Cell Line, Immortalization, Transgene, RMCE, GOI, Vector, CHO, HEK293, GPCR, Cell Culture, Drug Development, Personalized, Medicine, Characterization phenotype, GMO, ECACC, Heterologous expression, Receptor, Ion Channel, High Throughput Screening, Protein Production, Antigen Presentation

Expansion of Functional Personalized Cells with specific Transgene combinations
Bilingual Translation by ABDC (ABDC
的雙語翻譯, By Lky)

https://lnkd.in/ggimMmdc

Fundamental research and drug development for personalized medicine necessitates cell cultures from defined genetic backgrounds. However, providing sufficient numbers of authentic cells from individuals poses a challenge. Here, we present a new strategy for rapid cell expansion that overcomes current limitations. Using a small gene library, we expanded primary cells from different tissues, donors, and species. Cell-type-specific regimens that allow the reproducible creation of cell lines were identified. In depth characterization of a series of endothelial and hepatocytic cell lines confirmed phenotypic stability and functionality. Applying this technology enables rapid, efficient, and reliable production of unlimited numbers of personalized cells. As such, these cell systems support mechanistic studies, epidemiological research, and tailored drug development.
   

Stable CHO GPCR cell line

    . Stable G-protein coupled receptor (GPCR)
. CHO cell lines for cell-based assays.  
. 
Available as single seed vials or as frozen, assay ready reagent.  
. Available via the European Collection of Authenticated Cell Cultures (ECACC).  
. All main GPCR subunits available (Gs, Gq/G11, Gi/G0).  
. Cell lines are published.  
. Clonally-derived, GMO class 1
https://www.inscreenex.de/products/gpcr-cell-lines/

Receptor   

Cell Line (ECACC Cat. No.)

GPCRdb

ADRB2 (ADRB2R, B2AR)
β2-adrenoceptor, beta-2 adrenergic receptor

10031601

Link

CHRM1
Muscarinic acetylcholine receptor M1

10110203

Link

CHRM2
Muscarinic acetylcholine receptor M2

10110204

Link

CHRM3

Muscarinic acetylcholine receptor M3

10031603

Link

CHRM5

Muscarinic acetylcholine receptor M5

11041302

Link

HRH2

Histamine H2 receptor, H2R, HH2R, Gastric receptor I

10031604

Link

FFAR2 (FFA2, GPCR43, GPR43)
Free fatty acid receptor 2, G-protein coupled receptor 43

10110202

Link

FFAR3 (GPR41)

Free fatty acid receptor 3, G-protein coupled receptor 41

10031602

Link

FFAR4 (GPR120, GPR129, O3FAR1, PGR4)

Free fatty acid receptor 4, G-protein coupled receptor 120, G-protein coupled receptor 129, G-protein coupled receptor GT01, G-protein coupled receptor PGR4, Omega-3 fatty acid receptor 1

10110205

Link

OPRL1 (OOR, ORL1, NOPR) Nociceptin receptor, Kappa-type 3 opioid receptor, KOR-3, Orphanin FQ receptor

10110201

Link

SSTR1
Somatostatin receptor type 1, SS-1-R, SS1-R, SS1R, SRIF-2

10110206

Link

GCGR 

Glucagon receptor, GL-R

10031605

Link

 

 




Immortalized Cell Lines  
Species : Human, Mouse, Chicken, Sheep, Pig/Swine, Llama/Camelid, Cow/Cattle, Dog, Cat, Rat
Cell Types

1. Epithelial Cells

2. Endothelial Cells

3. Stromal Cells

4. CNS/PNS/ENS Cells

5. Musculoskeletal cells

Alveolar Epithelial Cells

Microvascular Endothelial Cells

Fibroblasts (skin, gingiva)

Enteric Glial Cells

Chondrocytes

Airway Epithelial Cells

HUVECs

MSCs

Astrocytes

Osteoblasts

Thyroid Epithelial Cells

Lymphatic Endothelial Cells

Pericytes

Spinal Cord Neurons

Smooth Muscle Cells

Intestinal Epithelial Cells

Aortic Endothelial Cells

Wharton's Jelly MSCs

 

 

Hepatocytes

 

Cardiac Stromal Cells

 

 

Placenta Epithelial Cells

 

 

 

 

Kidney PTECs

 

 

 

 

Retinal Epithelial Cells

 

 

 

 

Nasal Epithelial Cells

 

 

 

 

Keratinocytes

 

 

 

 

Bronchial Epithelial Cells

 

 

 

 

Mammary Epithelial Cells

 

 

 

 

   


Cell Line Portfolio

 

Cell Culture Media and Supplements  
Optimized Cell Culture Media ensuring growth and maintenance of cellular properties, consisting of Basal Medium and corresponding Supplements.

Culture media :  
huAEC Medium, huAEC Medium, huChon Medium, Serum-Free huChon Medium, huFIB Medium, Serum-Free huFIB Medium, huMEC Medium, huOB Differentiation Medium, huOB Maintenance, Medium, huVEC Medium, huThyrEC Medium, muINTEPI Medium, muADINTESTI Medium, muMEC Medium

Coating solutions :  
Collagen solution (ready-to-use), from rat tails, suitable for cell culture
Collagen solution (ready-to-use), from rat tails, suitable for cell culture
Gelatin solution 2% (ready-to-use), suitable for cell culture
Gelatin solution 2% (ready-to-use), suitable for cell culture
huAEC Coating Solution (ready-to-use), suitable for cell culture
huAEC Coating Solution (ready-to-use), suitable for cell culture
huAEC Coating Solution (ready-to-use), suitable for cell culture
Epithelial Cell Coating Solution (ready-to-use), suitable for cell culture
Epithelial Cell Coating Solution (ready-to-use), suitable for cell culture

Various :  
Doxycycline solution (2 mg/ml), suitable for cell culture
Freezing medium (contains serum)
G418 solution (50 mg/ml), suitable for cell culture
Polybrene solution (8 μg/ml), suitable for cell culture.

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